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Can I see positive cooperativity from SPR binding curves?

  • AnnaJ
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3 years 4 months ago #1 by AnnaJ
Can I see positive cooperativity from SPR binding curves? was created by AnnaJ
Dear all,

does someone know if I can see positive cooperativity in binding from the SPR curves? I have a chemokine which may bind in this way to its receptor but I need to prove it. Do I need an analyte that does not have cooperativity as control or what would you suggest?

Thanks for all advice!

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  • Arnoud
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3 years 4 months ago #2 by Arnoud
Replied by Arnoud on topic Can I see positive cooperativity from SPR binding curves?
Hi,
I don't have experience with dis subject. Maybe the following publication wil help you:

www.ncbi.nlm.nih.gov/pmc/articles/PMC6423499/
med.emory.edu/departments/biochemistry/r...lasmon-resonance.pdf
www.ncbi.nlm.nih.gov/pmc/articles/PMC2034450/

Arnoud

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  • AnnaJ
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3 years 4 months ago #3 by AnnaJ
Replied by AnnaJ on topic Can I see positive cooperativity from SPR binding curves?
Thank you very much, Arnoud!

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